Freezing embryos for later transfer as half of assisted reproductive therapy doesn’t end in a higher probability of pregnancy in contrast with fresh embryo transfer, finds a research printed by The BMJ as we speak.
The researchers say the findings warrant warning in making use of an indiscriminate “freeze-all” strategy for all women present process assisted reproductive expertise therapy, and that fresh embryo transfer ought to be used because the gold normal.
A freeze-all technique also can minimise the danger of ovarian hyperstimulation syndrome (a painful response to hormones used to stimulate egg development), however research evaluating the 2 methods are missing.
To assist fill this proof hole, a group of researchers got down to take a look at whether or not a freeze-all technique resulted in a higher pregnancy fee than a fresh transfer technique.
Their findings are based mostly on 460 ladies aged 18-39 years with common menstrual cycles beginning their first, second, or third therapy cycle of in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI) at fertility clinics at eight public hospitals in Denmark, Sweden, and Spain.
Women have been randomised to at least one of two therapy teams.
The freeze-all group (elective freezing of all embryos) acquired gonadotropin releasing hormone to set off egg maturity, adopted by a single frozen-thawed mature egg (blastocyst) transfer.
The fresh transfer group acquired human chorionic gonadotropin to set off egg maturity, adopted by a single fresh blastocyst transfer.
Women within the fresh transfer group with an extra quantity of mature follicles (fluid-filled sacs containing an egg) on the day of triggering had elective freezing of all embryos and transfer was delayed as a security measure.
The outcomes present that the pregnancy fee (outlined as a detectable fetal coronary heart beat after eight weeks of gestation) didn’t differ considerably between the freeze-all and fresh transfer teams (62 out of 223 or 27.8% v 68 out of 230 or 29.6%).
In addition, no important distinction was discovered within the reside delivery fee, with 61 out of 223 or 27.4% for the freeze-all group and 66 out of 230 or 28.7% for the fresh transfer group.
No important variations between teams have been noticed for pregnancy loss, and none of the ladies had extreme ovarian hyperstimulation syndrome.
The dangers of problems didn’t differ between the 2 teams aside from a higher common delivery weight after frozen blastocyst transfer and an elevated threat of prematurity after fresh blastocyst transfer.
Time to pregnancy was longer within the freeze-all group.
The researchers level to some research limitations which will have influenced their outcomes, however they are saying “in women with regular menstrual cycles, a freeze-all strategy with gonadotropin releasing hormone agonist triggering did not result in higher ongoing pregnancy and live birth rates than a fresh transfer strategy.”
What’s extra, “a safe fresh embryo transfer strategy can be applied to women with regular menstrual cycles with strict cancellation criteria for the fresh transfer if an excess number of mature follicles are present,” they add.
“The findings warrant caution in the indiscriminate application of a freeze-all strategy when no apparent risk of ovarian hyperstimulation syndrome is present,” they conclude.
Freeze-all versus fresh blastocyst transfer technique throughout in vitro fertilisation in ladies with common menstrual cycles: multicentre randomised managed trial, DOI: 10.1136/bmj.m2519
British Medical Journal
Chances of pregnancy no higher with frozen over fresh embryo transfer (2020, August 5)
retrieved 5 August 2020
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