COVID-19 Prevention Network launches two research studies evaluating monoclonal antibodies

0
44


COVID-19 Prevention Network launches two research studies evaluating monoclonal antibodies
The COVID-19 Prevention Network (CoVPN) right this moment introduced two Phase three trials to find out whether or not monoclonal antibodies (mAbs) can stop SARS-CoV-2, the virus that causes COVID-19. Credit: CoVPN

The COVID-19 Prevention Network (CoVPN) right this moment introduced two Phase three trials to find out whether or not monoclonal antibodies (mAbs) can stop SARS-CoV-2, the virus that causes COVID-19. The first trial, CoVPN 3501, will consider LY-CoV555, an Eli Lilly and Company mAb to see whether or not it might stop SARS-CoV-2 an infection amongst folks dwelling or working in expert nursing and assisted dwelling services. Scientists from the National Institute of Allergy and Infectious Diseases Vaccine Research Center and Abcellera Biologics found LY-CoV555. The trial will enroll as much as 2,400 members within the U.S. who will likely be randomized to obtain an intravenous infusion of LY-CoV555 or a placebo. The second trial, CoVPN 3502, will consider REGN-COV-2, a Regeneron Pharmaceutical double mAb mixture, to see if it would stop an infection amongst family contacts with shut publicity to somebody lately identified with COVID-19 that has been sustained for not less than 48 hours. The examine will enroll roughly 2,000 members within the U.S.

“Monoclonal antibodies may have the immediate potential to prevent COVID-19 acquisition,” stated Dr. Myron Cohen, CoVPN co-principal investigator and director of the Institute for Global Health on the University of North Carolina at Chapel Hill. “This is particularly necessary amongst teams most vulnerable to COVID-19, such because the , these with underlying , and those at high risk of exposure because someone in their household is infected.”

Monoclonal antibodies are proteins manufactured in a laboratory that assist our our bodies struggle an infection, delivered by way of an intravenous infusion (i.e., by way of a vein) or injection. Nearly 100 mAbs are accredited to deal with varied ailments and situations, together with cancers and autoimmune ailments. Besides exploring COVID-19 prevention and therapy roles, mAbs are being studied to deal with and stop HIV.

“The CoVPN is excited to partner with government and industry experts to identify safe and effective treatment options to reduce the global impact of COVID-19,” stated Dr. David Stephens, CoVPN co-principal investigator and chair of the Emory University Department of Medicine in Atlanta. “Monoclonal antibodies may be our best hope until we have a viable vaccine.”

The U.S. National Institute of Allergy and Infectious Diseases (NIAID), a part of the U.S. National Institutes of Health (NIH) is funding each scientific trials. Eli Lilly and Company, and Regeneron Pharmaceuticals are offering examine merchandise.

For extra details about REGN-COV-2, go to ScientificTrials.gov utilizing the examine identifier NCT04452318. For LY-CoV555, use the examine identifier NCT04497987.


Follow the latest news on the coronavirus (COVID-19) outbreak


Provided by
HIV Prevention Trials Network (HPTN)

Citation:
COVID-19 Prevention Network launches two research studies evaluating monoclonal antibodies (2020, August 11)
retrieved 11 August 2020
from https://medicalxpress.com/information/2020-08-covid-network-monoclonal-antibodies.html

This doc is topic to copyright. Apart from any honest dealing for the aim of personal examine or research, no
half could also be reproduced with out the written permission. The content material is supplied for data functions solely.





Source link

Leave a Reply