Dr. Abhishek Jain, assistant professor within the Department of Biomedical Engineering and the Department of Medical Physiology within the College of Medicine, collaborated with researchers from the Departments of Gynecologic Oncology and Cancer Biology at MD Anderson Cancer Center to realize a greater understanding of the interplay amongst ovarian cancer tumors, blood vessels and platelets. They discovered that tumors break the blood vessel limitations in order that they will talk with the blood cells, resembling platelets. When these tumors come into contact with platelets, they will then metastasize, or start to unfold to different websites within the physique.
The collaborative research was not too long ago printed within the journal Blood Advances.
Currently, researchers perceive that platelets are one of many initiators of ovarian cancer metastasis however didn’t know what led to the introduction of the platelets to the tumor cells. Instead of struggling to view this relationship in animal fashions, Jain’s workforce introduced a brand new answer to the desk: organ-on-a-chip analysis.
Organs-on-a-chip are microfluidic medical units the dimensions of a USB drive. The workforce designed on the OvCa-Chip to offer researchers a better window to view the organic processes between tumors and platelets.
In an interview with the International Society on Thrombosis and Hemostasis, Jain defined that “it basically is a microenvironment where ovarian tumor cells can be co-cultured along with their blood vessels, and then they can interact with blood cells. Once we learn about these interactions, we can then move forward to look into how drugs will impact these kinds of interactions.”
Viewing the interplay between tumors and blood vessels on the OvCa-Chip led the researchers to a unprecedented outcome—the tumor cells systematically broke down the endothelial cells, that are the barrier that strains the inside floor of blood vessels and prevents exterior interplay with blood cells. Once this barrier was gone, blood cells and platelets entered the tumor microenvironment and might be recruited for metastasis.
Harnessing this information may change how clinicians strategy ovarian cancer therapy, Jain stated, suggesting that anti-vascular medicine might be thought-about together with anticancer therapies. A advantage of the organ-on-a-chip is that it could actually additionally check these novel drug therapies and drug combos.
Another software of the chips might be diagnostics.
“You have to understand that these are chips that are living. They contain living cells. The advantage is that these are all actually human samples,” Jain said within the interview. “So what we think the future for this technology is, is perhaps we can advance it in the direction of personalized medicine where we could actually take stem cells from patients and other patient-derived cells and make this entire chip from a single patient.”
Biswajit Saha et al, OvCa-Chip microsystem recreates vascular endothelium–mediated platelet extravasation in ovarian cancer, Blood Advances (2020). DOI: 10.1182/bloodadvances.2020001632
Texas A&M University
Exploring connections between ovarian cancer and blood cells (2020, August 14)
retrieved 14 August 2020
This doc is topic to copyright. Apart from any honest dealing for the aim of personal examine or analysis, no
half could also be reproduced with out the written permission. The content material is supplied for info functions solely.