New microrobot with in situ, in vivo bioprinting offers promise for gastric wounds



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Researchers in China have taken step one in the direction of a brand new approach of treating gastric wounds through the use of a microrobot mixed with the brand new idea of “in situ in vivo bioprinting” to hold out tissue restore contained in the physique.

Their research, revealed right now in the IOP Publishing journal Biofabrication, establishes proof-of-concept for this new methodology in the sector of bioprinting.

Co- creator Professor Tao Xu, from Tsinghua University, Beijing, mentioned: “Gastric wall injury is a common problem in the digestive tract, and about 12 percent of the world’s population suffer from it to varying degrees. Bioprinting—delivering new on to the wound website to restore the tissue—offers a probably very helpful approach to deal with the issue.

“The difficulty is that current bioprinting technology focuses on external sites. Bioprinters are normally quite large, and cannot be applied to inner without invasive surgery to give enough room for the printing operation. To overcome this, we developed a microrobot that enters the body via an endoscope to carry out tissue repair inside the body.”

The bioprinting platform Professor Xu and the co-author, Professor Xu’s Ph.D. pupil Wenxiang Zhao developed is a Delta robotic composed of a set base, transferring platform and three similar kinematic chains. To be as minimally-invasive as doable, it could actually fold itself down when getting into the sufferers’ physique, then unfold earlier than starting the bioprinting operation.

Mr. Zhao, additionally from Tsinghua University, mentioned: “We examined the system in two methods. First, with a organic mannequin of a human abdomen and an endoscope, to imitate the insertion and printing operation components of the method. Second, we carried out a bioprinting check in a cell tradition dish to check how efficient the machine was at bioprinting viable cells and repairing wounds.

“Both tests showed promising results. A 10-day cell culture showed that printed cells remained at a high viability and a steady proliferation, which indicated good biological function of the cells in printed scaffolds.”

Professor Xu added: “Although only a first step, this study has verified the feasibility of this concept for treatment for gastric wall injuries. More work is needed to bring it to full realisation, including reducing the size of the platform and developing bioinks. Our future studies will concentrate on these areas.”

Mapping the future direction for bioprinting research

More data:
Wenxiang Zhao et al, Preliminary engineering for in situ in vivo bioprinting: a novel micro bioprinting platform for in situ in vivo bioprinting at a gastric wound website, Biofabrication (2020). DOI: 10.1088/1758-5090/aba4ff

New microrobot with in situ, in vivo bioprinting offers promise for gastric wounds (2020, August 12)
retrieved 12 August 2020

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