Men at specific danger for HIV are very more likely to constantly take prevention medication throughout holidays when their odds of contracting the virus are increased, based on a brand new examine led by scientists on the University of Pittsburgh Graduate School of Public Health, The Fenway Institute and Harvard University.
The findings, printed on-line and to be reported Saturday within the print subject of the Journal of Acquired Immune Deficiency Syndromes, point out that short-term use of pre-exposure prophylaxis (PrEP) medication might be a extremely profitable technique to forestall the unfold of HIV in men who’ve intercourse with men and have problem with long-term PrEP use. It can also work to transition men to long-term PrEP use, which has been proven to be extremely efficient in lowering HIV transmission.
“We started this as a feasibility study to see if we could identify barriers to short-term PrEP use and make adjustments. But we were excited when we got the results and discovered that almost all the participants were adherent to the point of protection against HIV,” stated lead creator James Egan, Ph.D., M.P.H., assistant professor of behavioral and neighborhood well being sciences at Pitt Public Health. “This gives us a promising strategy to pursue in engaging at-risk men in HIV prevention efforts that work for them.”
When taken as a every day tablet, PrEP reduces the chance of getting HIV from intercourse by about 99%, based on the Centers for Disease Control and Prevention. However, adhering to a every day medication routine does not work for everybody for causes that embrace value and particular person considerations concerning the organic penalties of long-term medication.
Previous research have proven that there are specific durations when men who’ve intercourse with men are extra weak to contracting HIV, together with when touring, on vacation, shifting to a brand new metropolis or after a break-up. Egan and his staff got down to discover whether or not these men is likely to be extra receptive to adhering to PrEP therapy throughout these occasions.
The staff adopted 48 grownup men from Pittsburgh or Boston who’ve intercourse with men in a pilot program to check the every day use of PrEP for 30 days that included an out-of-town vacation, with the men beginning the medication seven days earlier than the journey and persevering with for at the least seven days after vacation. The men have been additionally given a quick session introducing them to the use of PrEP.
After their holidays, 94% of the men had blood concentrations protecting in opposition to HIV, according to common use of the medication. Almost 75% reported condomless intercourse throughout vacation, and a couple of third reported leisure drug use. None of the men contracted HIV throughout their vacation, although one of the men contracted the virus throughout the three-month post-vacation follow-up interval when he’d had a lapse in use of PrEP related to loss of medical health insurance and a transfer to a brand new metropolis.
Additionally, 70% of the members indicated an curiosity in persevering with every day PrEP use long-term.
“That really stood out to us,” stated senior creator Kenneth Mayer, M.D., medical analysis director at The Fenway Institute at Fenway Health in Boston and professor of drugs at Harvard. “It shows us that introducing short-term use of PrEP before a vacation could lead to longer-term use. This presents an enticing opportunity to reduce HIV transmission.”
However, the scientists identified, the examine included men who have been motivated to enroll and didn’t tackle the chance of physicians prescribing PrEP for short-term use, the benefit of acquiring PrEP for use solely throughout holidays or the impression of the examine’s temporary counseling on the use of PrEP.
“These are all areas that our findings suggest warrant future explorations,” Egan stated. “Our study tells us short-term adherence to PrEP during high-risk periods is tolerable in men who have sex with men, and that it could lead to long-term use. Now we need to determine how to make it possible in the real-world setting.”
James E. Egan et al, Feasibility of Short-Term PrEP Uptake for Men who Have Sex with Men with Episodic Periods of Increased HIV Risk, JAIDS Journal of Acquired Immune Deficiency Syndromes (2020). DOI: 10.1097/QAI.0000000000002382
University of Pittsburgh
Short-term use of HIV-prevention medication protects at-risk men on vacation (2020, August 12)
retrieved 12 August 2020
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